Histone and DNA Methylation–Mediated Epigenetic Downregulation of Endothelial Kruppel-Like Factor 2 by Low-Density Lipoprotein Cholesterol - Concepedia

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Histone and DNA Methylation–Mediated Epigenetic Downregulation of Endothelial Kruppel-Like Factor 2 by Low-Density Lipoprotein Cholesterol

133

Citations

33

References

2013

Year

Ajay Kumar, Santosh Kumar, Ajit Vikram, Timothy A. Hoffman, Asma Naqvi, Christopher Lewarchik, Young‐Rae Kim, Kaikobad Irani

Arteriosclerosis Thrombosis and Vascular Biology

Abstract

LDL represses endothelial KLF2 expression via DNA and histone methylation. Downregulation of KLF2 by LDL leads to a dysfunctional, hypercoagulable endothelium.

References

	Year	Citations

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