Stochastic Sensing of Polynucleotides Using Patterned Nanopores

Abstract

Electric-field driven translocation of a DNA or RNA molecule across a nanopore has been widely explored as a method for molecular sequencing. But, the process is inherently noisy. Finding ways to fight the noise seems a matter of course. Here, however, a UK team demonstrates a clever way to turn the noise into gains towards fast and accurate molecular sequencing.