Psychiatry and Clinical Neurosciences · 1991 · 14 citations · 7 references
MedicineNeurologyNeuroscienceNeuroimmunologyNeuromuscular DisordersNeuropathologyDemyelinating DiseasesDemyelinating DisordersOptic NervePeripheral Nerve BiopsyPeripheral Nerve DisordersPeripheral NeuropathiesDemyelination PathophysiologyDevic DiseaseOptic Nerve DemyelinationPeripheral Nerve DemyelinationPeripheral Nervous System DisordersPeripheral Nervous System MyelinPeripheral Neuropathy PathophysiologySural Nerve Biopsy
This is a report of a 20-year-old man with typical features of Devic disease (neuromyelitis optica) associated with demyelinating peripheral neuropathy. A sural nerve biopsy showed markedly decreased myelinated fibers of a large diameter. Teased fiber preparations showed segmental remyelination in 50% of examined fibers, as well as a few demyelination. Demyelination of bilateral optic nerves, spinal cord, and peripheral nerves at the same time suggests a possibility of common pathogenetic mechanisms in both the central and peripheral nervous systems.
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