Effectiveness of Topical Immunosuppressants in Prevention and Treatment of Rejection in Face Allotransplantation

Abstract

Both topical tacrolimus and clobetasol were effective in treating episodes of acute rejection, and the best outcomes were achieved when their application was initiated after systemic immunosuppression. Topical tacrolimus proved to be a preferable adjunct agent to the systemic therapy by preventing both the local and systemic complications.