Expression of hypoxia-inducible factor 1? by macrophages in the rheumatoid synovium: Implications for targeting of therapeutic genes to the inflamed joint

Abstract

These observations indicate that macrophages transduced with a therapeutic gene under the control of a hypoxia-inducible promoter could be administered to RA patients systemically. Migration of these cells to synovial tissue would result in the transgene being switched on in diseased joints but not in healthy tissues.