Glomerular Capillary Thrombosis and Acute Renal Failure after Epsilon-Amino Caproic Acid Therapy

Abstract

WITH increased awareness of the hemorrhagic syndromes produced by spontaneous intravascular coagulation or fibrinolysis, there has been increased use of epsilon-amino caproic acid (EACA, Amicar) as a therapeutic agent. This, in turn, has led to recognition of a number of its toxic side effects.1 , 2 Hypotension, one of its known side effects,1 , 2 could produce acute tubular necrosis and thus precipitate acute renal failure. Intraureteral clot formation, reported after the use of EACA for treatment of hematuria in patients with hemophilia,1 2 3 if bilateral could also result in anuria and renal failure. The following case illustrates the development of oliguria and renal failure . . .