Species difference in the modulatory effect of κ agonist on 5-HT release from ground squirrel and rat hippocampus

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Pharmacology, Neuroendocrinology +9

Organization of ascending serotonin systems in the adult rat brain. A radioautographic study after intraventricular administration of [3h]5-hydroxytryptamine

André Parent, L. Descarries, Alain Beaudet · Neuroscience · 1981 · 527 citations

Medicine, Neurobiology, Neuroscience +15

Multiple Opiate Receptors: Different Regional Distribution in the Brain and Differential Binding of Opiates and Opioid Peptides

Kwen-Jen Chang, Barrett R. Cooper, Eli Hazum et al. · Molecular Pharmacology · 1979 · 410 citations

Medicine, Neuroscience, Pharmacology +15

Discrete mapping of brain mu and delta opioid receptors using selective peptides: Quantitative autoradiography, species differences and comparison with kappa receptors

N.A. Sharif, Joel W. Hughes · Peptides · 1989 · 208 citations

Medicine, Neurobiology, Neuroscience +16