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MODE OF ACTION OF SULFANILAMIDE
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1938
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ImmunohematologyAntimicrobial ChemotherapyChemistryBacterial PathogensPharmaceutical ChemistryMarrow Culture TechnicMedical MicrobiologyHematologyBone MarrowMarrow CellsInfection ControlAntimicrobial ResistanceAerobic CulturingHealth SciencesMicrobial ToxinMode Of ActionMechanism Of ActionPharmacologyClinical MicrobiologyAntimicrobial SusceptibilityAntibioticsMicrobiologyMedicine
<h3>To the Editor:—</h3> The article by Dr. Osgood and Miss Brownlee (The Journal, January 29, p. 349), reporting an investigation of the mode of action of sulfanilamide by use of their marrow culture technic, represents an important contribution to the literature on this subject. Culture of the bone marrow provides a favorable device for investigating the reactions of these cells both to sulfanilamide and to the beta type hemolytic streptococci, alone and in combination. Especially interesting is the observation of the authors that living streptococci and marrow cells can exist together in culture for days without damage to the cells, provided a sufficient concentration of sulfanilamide is maintained. However, it does not seem necessary to postulate any direct action of the drug on the toxins of this organism in order to explain this action, especially since a bacteriostatic action of the drug has not been excluded by their experiments. Their