Chiral Separation of β₂‐Blockers on Pirkle‐Type Chiral Stationary Phases

Abstract

Abstract Liquid chromatographic resolution of six racemic β2‐blockers including bambuterol, clenbuterol, clenpropol, fumoterol, mabuterol, and terbutaline was studied on two Pirkle‐type chiral stationary phases (CSPs) such as α‐Burke‐2 and Pirkle‐1J. By varying the mobile phase compositions, five of the six β2‐blockers were successfully resolved on α‐Burke‐2 CSP, while only two β2‐blockers were resolved on Pirkle‐1J CSP.