Concepedia

Publication | Closed Access

Protein Tyrosine Phosphatase Nonreceptor Type 2 Regulates Autophagosome Formation in Human Intestinal Cells

DOI

70

Citations

41

References

2011

Year

Michael Scharl, Kacper A. Wojtal, Helen M. Becker, Anne Fischbeck, Pascal Frei, Joba M. Arikkat, Theresa Pesch, Silvia Kellermeier, David L. Boone, Achim Weber,
Inflammatory Bowel Diseases

Abstract

Our results demonstrate that PTPN2 regulates autophagosome formation in human intestinal cells. We provide a model of how a dysfunction of the CD susceptibility genes, PTPN2 and/or ATG16L1, may contribute to the onset and perpetuation of chronic intestinal inflammation.

References

YearCitations

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