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FURTHER STUDIES REGARDING THE QUESTION OF CELLULAR IMMUNITY IN MOUSE TYPHOID
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1968
Year
InflammationHost ResponseLaboratory ImmunologyAdaptive Immune SystemPathogenesisImmunologyUnrelated Rough StrainHumoral ImmunityT Cell ImmunityLiving VaccinesHost-microbe InteractionInfection ControlCellular Immune ResponseMedicineCell BiologyClinical MicrobiologySalmonella Typhimurium Infections
Summary The immunity of mice to Salmonella typhimurium infections has been investigated, using killed and living vaccines of the specific organism and also an apparently unrelated rough strain of Salmonella enteritidis 11RX. It is concluded from the result of these experiments that treatment of mice, with living vaccines of both strains, that leads to immunity to S. typhimurium infection is dependent on an increased bactericidal activity of the macrophage population which requires specific antibody for its expression.