Changes in pulmonary function and oxygenation during application of perfluorocarbon vapor in healthy and oleic acid-injured animals

Abstract

Healthy animals tolerated perfluorohexane vapor well without significant changes in oxygenation and mechanical lung function for 2 hrs. In injured animals, application of perfluorohexane vapor primarily improved peak inspiratory pressure and compliance. The increase of oxygenation therefore could be secondary to an improvement in compliance.