Chromosome 7 deletions are associated with unfavorable prognosis in myelofibrosis with myeloid metaplasia

Abstract

Several studies suggest a poor prognosis for patients with myelofibrosis (MF) with an abnormal karyotype, but the prognostic impact of specific cytogenetic lesions is difficult to define.[1][1] Using conventional cytogenetics, Tefferi et al were able to demonstrate that +8 and 12p- were associated