Incretin Hormone and Insulin Responses to Oral<i>Versus</i>Intravenous Lipid Administration in Humans

Abstract

At matching triglyceride levels and with no difference in glucose and free fatty acid levels, oral lipid ingestion but not iv lipid infusion elicits a clear insulin response in association with increased GIP and GLP-1 concentrations. This may suggest that the incretin hormones also contribute to the islet response to noncarbohydrate nutrients.