One‐Pot Synthesis of Functionalized 3‐(Trifluoromethyl)phenols by [3+3] Cyclization of 1,3‐Bis(silyl enol ethers) with α,β‐Unsaturated Trifluoromethyl Ketones

Abstract

Abstract Functionalized 3‐(trifluoromethyl)phenols were prepared by formal [3+3] cyclization of 1,3‐bis(silyl enol ethers) with readily available open‐chained and cyclic α,β‐unsaturated trifluoromethyl ketones. The reaction of 3,4‐dihydro‐5‐(trifluoroacetyl)‐2 H ‐pyran with 1,3‐bis(silyl enol ethers) resulted in a domino process to give new functionalized dihydropyrans. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)