Regulation of Glucose Uptake by Endothelin-1 in Human Skeletal Muscle<i>in Vivo</i>and<i>in Vitro</i>

Abstract

ET(A)/ET(B) receptor blockade enhances basal and insulin-stimulated glucose uptake in IR subjects. ET-1 directly impairs glucose uptake in skeletal muscle cells via a receptor-dependent mechanism. These data suggest that ET-1 regulates glucose metabolism via receptor-dependent mechanisms in IR subjects.