Aberrant Expression of Hypoxia-inducible Factor 1 , TWIST and E-cadherin is Associated with Aggressive Tumor Phenotypes in Endometrioid Endometrial Carcinoma

Abstract

These results demonstrated for the first time that the hypoxia-inducible factor 1α/TWIST/E-cadherin pathway may play a critical role in invasion and metastasis of endometrioid endometrial carcinoma. The combined evaluation of these markers may be useful in predicting aggressive phenotypes and thus prognosis in patients with endometrioid endometrial carcinoma.