Bacterial Contamination of Autologous Bone Marrow: Reinfusion of& ;Culture-Positive Grafts Does Not Result in Clinical Sequelae during the Posttransplantation Course

Abstract

(1) Collection and/or ex vivo processing can result in microbiological contamination of BM grafts predominantly with bacteria from the skin flora, and (2) only CNSC can be cultured at thawing from previously contaminated/cryopreserved BM. Since patients undergoing ABMT usually receive oral antibiotics from beginning of the conditioning regimen which are active against CNSC, no further administration of antibiotics is recommended for the reinfusion of bacterially contaminated BM grafts.