Sequence determination of actagardine, a novel lantibiotic, by homonuclear 2D NMR spectroscopy.

Abstract

By combination of several 1H NMR techniques, the sequence of actagardine has been elucidated. It has been shown that it is a tetracyclic 19-residue peptide antibiotic. It differs from the previously described lanthionine-containing peptide antibiotics belonging to the lantibiotic class.