Concepedia

Dual Effects of Isoflurane on Proliferation, Differentiation, and Survival in Human Neuroprogenitor Cells

Xuli Zhao, Zeyong Yang, Liang Ge, Zhen Wu, Yi Peng, Donald J. Joseph, Saadet Inan, Huafeng Wei

Anesthesiology · 2013 · 102 citations · 48 references

DOIFull text

Open access

Abstract

The commonly used general anesthetic isoflurane exerts dual effects on neuronal stem cell survival, proliferation, and differentiation, which may be attributed to differential regulation of calcium release through activation of endoplasmic reticulum localized inositol-1,4,5-trisphosphate and/or ryanodine receptors.

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