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Synthesis of New Water‐Soluble DNA‐Binding Subunits for Analogues of the Cytotoxic Antibiotic CC‐1065 and Their Prodrugs
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Citations
20
References
2006
Year
Peptide ScienceAntimicrobial ChemotherapyChemical BiologyPharmaceutical ChemistryMedicinal ChemistryCytotoxic Antibiotic Cc‐1065Their ProdrugsAnti-cancer AgentAntimicrobial Drug DiscoveryTertiary Amino FunctionalityBiochemistrySelective TreatmentDiversity-oriented SynthesisBioconjugationAntimicrobial CompoundDrug DevelopmentPharmacologyNew AnaloguesNatural SciencesMedicineSmall MoleculesDrug Discovery
Abstract Novel water‐soluble indole‐2‐carboxylic acid derivatives ( 7 , 13 , 21 and 25 ) bearing a substituent with a tertiary amino functionality at C‐5 have been prepared. These new DNA‐binding subunits can be used for the synthesis of new analogues of the cytotoxic antibiotic CC‐1065 and their corresponding prodrugs for antibody‐directed enzyme prodrug therapy (ADEPT) within a selective treatment of cancer.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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