Circadian rhythm of melatonin and prostaglandin in modulation of stress‐induced gastric mucosal lesions in rats

Abstract

These results suggest that circadian rhythm has an important role in the formation of stress-induced gastric mucosal lesions in rats. The circadian rhythm of melatonin responses and PGE2 generation may contribute to nocturnal/diurnal rhythmicity of gastric mucosal defences between day and night.