Tanshinone IIA Promotes Pulmonary Artery Smooth Muscle Cell Apoptosis<b><i>in Vitro</i></b>by Inhibiting the JAK2/STAT3 Signaling Pathway

Abstract

These data suggest that Tanshinone IIA promotes PASMC apoptosis during hypoxia and reverses vascular remodeling. This effect is mediated by modulating the expression of Hsp60, caspase-3, and Cx43 via the JAK2/STAT3 signaling pathway. These results might provide a new therapeutic target to explore a novel strategy for hypoxia-induced vessel remodeling.