A Novel Conformationally Constrained Parallel G Quadruplex

Abstract

Conducting a G quartet. We have devised a peptidic scaffold as a topological template that directs the intramolecular assembly of covalently attached oligonucleotides into stable G quadruplexes that are exclusively constrained in a parallel-stranded conformation. Using this scaffold together with SPR we have analyzed the molecular interactions of ligands for a single conformation of G quadruplex. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.