EFFECTS OF PUROMYCIN, ACETOXYCYCLOHEXIMIDE AND ACTINOMYCIN D ON PROTEIN SYNTHESIS IN GOLDFISH BRAIN*

Abstract

EXPERIMENTS in our laboratory have demonstrated that memory fixation of a shockavoidance task in the goldfish can be blocked by puromycin or acetoxycycloheximide (AXM)$ when administered within 1 hr after training, but not at later times (AGRANOFF and KLINGER, 1964; DAVIS, BRIGHT and AGRANOFF, 1965; AGRANOFF, DAVIS and BRINK, 1965, 1966).The present studies report the effects of these compounds as well as actinomycin D on the incorporation of [3H]leucine into goldfish brain protein.