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A retro-malonate addition reaction: synthesis of 3,4-condensed heteroaromatic pyrroles
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1988
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DerivativesBromo Alkylidenemalonates3,4-Condensed Heteroaromatic PyrrolesNatural SciencesDiversity-oriented SynthesisRetro-malonate Addition ReactionOrganic ChemistryStereoselective SynthesisChemistryHeterocycle ChemistrySame MethodPharmacologySynthetic ChemistryEnantioselective Synthesis
Treatment of bromo alkylidenemalonates (1)–(4) with ammonia or amines afforded 3,4-condensed heteroaromatic pyrroles (5)–(8) in excellent yields; benzotripyrroles (19)–(21) were synthesized by the same method.