IMMUNOHISTOCHEMICAL CHARACTERIZATION OF INFLAMMATORY AND PROLIFERATIVE EVENTS DURING CHRONIC REJECTION IN RAT LUNG ALLOGRAFTS1

Abstract

Inadequate immunosuppression of rat lung allografts leads primarily to chronic vascular rejection but fails to induce severe and diffuse development of OB. In this animal model, cytokines IL-1beta, IL-8, and bFGF are likely to play an important role in the early inflammatory phase but not during the late proliferative events of chronic rejection.