Green Chemistry · 2013 · 121 citations · 42 references
Natural SciencesChemical EngineeringChemistryCatalysisOrganic ChemistryCatalyst SynthesisCross-coupling ReactionsHeterocycle SynthesisCopper-catalyzed CouplingHeterocycle FunctionalizationMild Reaction ConditionsPyrrole ChemistryPyrrole SynthesisStereoselective Cross-coupling
A novel and efficient copper-catalyzed homocoupling of ketoxime carboxylates has been developed for the synthesis of symmetrical pyrroles. This reaction tolerates a wide range of functional groups and provides a synthetically useful process to synthesize valuable symmetrical pyrroles under mild conditions.
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A sustainable catalytic pyrrole synthesis
Stefan Michlik, Rhett Kempe · Nature Chemistry · 2013 · 486 citations