The Inhibition of Platelet Aggregation by Biscoclaurine Alkaloids

Abstract

The effects of biscoclaurine alkaloids on ADP-or collagen-induced platelet aggregation were examined as alkaloids are known to inhibit lipid peroxidation (1, 7) and stabilize labilized biomembranes (8, 9). Most alkaloids greatly inhibit the platelet aggregation induced by ADP or collagen. This inhibition was concentration dependent and significantly higher where there was collagen aggregation.