Binuclear cyclopalladated compounds with antitubercular activity: synthesis and characterization of [{Pd(C²,N-dmba)(X)}₂(<i>μ</i>-bpp)] (X = Cl, Br, NCO, N₃; bpp = 1,3-bis(4-pyridyl)propane)

Abstract

Reactions between [Pd(C-2,N-dmba)(mu-X)](2) (Hdmba = N,N-dimethylbenzylamine; X = Cl, Br, NCO, N-3) and 1,3-bis(4-pyridyl)propane (bpp) in 1 : 1 molar ratio at room temperature resulted in the binuclear compounds [{Pd(C-2,N-dmba)(X)}(2)(mu-bpp)] (X = Cl (1), Br (2), NCO (3), N-3 (4)), which were characterized by elemental analyses, infrared (IR), H-1- and C-13{H-1}-NMR spectroscopies, and thermogravimetric analysis. The IR and NMR data of 1-4 were consistent with the presence of bridging bpp. The thermal stability order of the complexes was 4 &gt; 3 &gt; 2 &gt; 1. Compounds 1-4 and bpp were tested against Mycobacterium tuberculosis and their MIC values were determined.