Globostellatic Acids A−D, New Cytotoxic Isomalabaricane Triterpenes from the Marine Sponge <i>Stelletta globostellata</i>

Abstract

Four new cytotoxic triterpenes, globostellatic acids A-D (1-4), have been isolated from the marine sponge Stelletta globostellata. Their structures have been determined by interpretation of spectral data. They exhibited cytotoxicity against P-388 murine leukemia cells with IC50 values of 0.1-0.46 microgram/mL.