Transcriptional regulation of the human reduced folate carrier promoter C: synergistic transactivation by Sp1 and C/EBP β and identification of a downstream repressor

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

Albert J. Courey, Robert Tjian · Cell · 1988 · 1.4K citations

Transcriptional Regulation, Signal Transduction, Natural Sciences +12

Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction

Robert M. Horton, Zeling Cai, Steffan N. Ho et al. · BioTechniques · 2013 · 1.3K citations · Full text

Tailor-made Genes, Genetics, Gene-gene Interactions +19

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

Erica Pascal, Robert Tjian · Genes & Development · 1991 · 438 citations · Full text

Multiple Sp1 Sites, Molecular Regulation, Sp1 Govern Formation +18

Defective Transport Is a Common Mechanism of Acquired Methotrexate Resistance in Acute Lymphocytic Leukemia and Is Associated With Decreased Reduced Folate Carrier Expression

Richard Görlick, Erdem Göker, Tanya Trippett et al. · Blood · 1997 · 186 citations · Full text

Mechanisms of methotrexate resistance in osteosarcoma.

Wei Guo, John H. Healey, Paul A. Meyers et al. · PubMed · 1999 · 154 citations

Tumor Biology, Oncogenic Agent, Medicine +12