Optimization of nucleophilic fluorination step in the synthesis of various compounds labelled with fluorine‐18 for their use as pet radiotracers

Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution.

K. Hamacher, Heinz H. Coenen, G. Stöcklin · PubMed · 1986 · 1.4K citations

Synthesis Time, Nucleophilic Fluorination, Medicinal Chemistry +13

Separation of [18F]fluoride from [18O]water using anion exchange resin

David J. Schlyer, Miguel Α. V. Bastos, David Alexoff et al. · International Journal of Radiation Applications and Instrumentation Part A Applied Radiation and Isotopes · 1990 · 97 citations

Anion Exchange Resin, Chemical Engineering, Engineering +7

Basic hydrolysis of in the preparation of 2-[18F]fluoro-2-deoxy-d-glucose

F. Füchtner, Jörg Steinbach, P. Mäding et al. · Applied Radiation and Isotopes · 1996 · 76 citations

Bioorganic Chemistry, Biochemistry, Natural Sciences +6

N.C.A. [¹⁸F]‐labelling of aliphatic compounds in high yields via aminopolyether ‐ supported nucleophilic substitution

Dirk Block, Bernd Klatte, Arndt Knöchel et al. · Journal of Labelled Compounds and Radiopharmaceuticals · 1986 · 67 citations

High Yields, High Ion Concentration, Chemical Engineering +15

Extraction of [18F]fluoride from [18O]water by a fast fibrous anion exchange resin

Douglas M. Jewett, Steven A. Toorongian, Michael Bachelor et al. · International Journal of Radiation Applications and Instrumentation Part A Applied Radiation and Isotopes · 1990 · 22 citations · Full text

Solvent Extraction, Chemical Engineering, Engineering +6