Radiation Research · 1984 · 30 citations · 31 references
MedicineCell BiologyGeneticsDna RepairRadiation DosimetryRadiobiologyBiological Effects Of RadiationCellular Radiation ResponseHigh-dose Radiation EffectsLow-dose Radiation EffectsRadiation SensitivityRadiation ToxicityCellular Radiation DamageCellular RadiosensitivityGenetic Determinants Of RadiosensitivityIntrinsic RadiosensitivityRadiation DefectsRadiation Dose EffectsRadiobiological ResponseXeroderma Pigmentosum
Cells from 11 human strains, including fibroblasts from patients with the genetic diseases of ataxia telangiectasia (AT), xeroderma pigmentosum (XP), and Fanconi's anemia (FA), were exposed to gamma radiation at high (1.6-2.2 Gy/min) and at low (0.03-0.07 Gy/min) dose rates. Survival curves reveal an increase in the terminal slope (D0) when cells are irradiated at low dose rates compared to high dose rates. This was true for all cell lines tested, although the AT, FA, and XP cells are reported or postulated to have radiation repair deficiencies. From the response of these cells, it is apparent that radiation sensitivities differ; however, at low dose rate, all tested human cells are able to repair injury.
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Defective Repair Replication of DNA in Xeroderma Pigmentosum
James E. Cleaver · Nature · 1968 · 1.7K citations
Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity
A. Malcolm R. Taylor, D.G. Harnden, C.F. Arlett et al. · Nature · 1975 · 989 citations
Jay H. Robbins, Kenneth H. Kraemer, Marvin A. Lutzner et al. · Annals of Internal Medicine · 1974 · 760 citations