Verongamine, a Novel Bromotyrosine-Derived Histamine H<sub>3</sub>-Antagonist from the Marine Sponge Verongula gigantea - Concepedia

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Verongamine, a Novel Bromotyrosine-Derived Histamine H<sub>3</sub>-Antagonist from the Marine Sponge Verongula gigantea

DOI Full Paper Access

44

Citations

0

References

1994

Year

Ronald Mierzwa, Arthur S. King, Michael A. Conover, S. Tozzi, Mohindar S. Puar, M.A. Patel, Stephen J. Coval, Shirley A. Pomponi

Journal of Natural Products

Abstract

The novel bromotyrosine derivative verongamine [1] has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H3 bioassay-guided fractionation. Verongamine is a specific histamine-H3 antagonist at concentrations as low as 1 microgram/ml.