Effect of Baclofen on Alcohol and Sucrose Self‐Administration in Rats

Abstract

Systemic baclofen administration attenuates responding for alcohol and sucrose reinforcement in a dose-dependent manner. If the reinforcing efficacy and response requirement for sucrose and alcohol are matched, then baclofen has similar effects on responding and patterns of drinking microstructure. We conclude that the neural mechanisms that support both ethanol and sucrose self-administration behavior are sensitive to gamma-aminobutyric acid type B modulation.