Glutamate and malate dehydrogenase activities in Joseph disease and olivopontocerebellar atrophy

Abstract

The activities of brain glutamate dehydrogenase and malate dehydrogenase were not statistically different in samples from patients with autosomal dominant olivopontocerebellar atrophy or Joseph disease compared with control subject samples. These two enzymes are thus not involved in the pathogenesis of these two separate dominantly inherited diseases.