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Asymmetric Hydrogenation of Cyclic Ketimines Catalyzed by Iridium(I)-Complexes of BCPM and Its Analog1
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1995
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Efficient LigandsInorganic ChemistryChemical EngineeringEnantioselective SynthesisEngineeringCoordination ComplexCyclic Ketimines CatalyzedOrganic ChemistryOrganometallic CatalysisCatalysisModified LigandsChemistryMolecular ComplexInorganic SynthesisAnalog MccpmAsymmetric Hydrogenation
Modified pyrrolidinebisphosphines, BCPM (1a) and its analog MCCPM (1b), were found to be more efficient ligands than the original BPPM (2a) in the iridium(I)-catalyzed asymmetric hydrogenation of imines in the presence of iodide. In particular, the modified ligands (1a,b) showed very high enantioselectivity of up to 91% ee in the hydrogenation of 2,3,3-trimethylindolenine (6) in the presence of bismuth(III) iodide.