PubMed · 1982 · 27 citations · 0 references
Medicinal ChemistryBiochemistryReactive Nitrogen SpecieMedicineNatural SciencesMetalloproteinBioactive MetalNitrosative StressNitroblue Tetrazolium ReductionToxicologyCopper ContentChemistryNadh-phenazine MethosulfatePharmacologyRedox BiologyXanthine OxidaseOxidative Stress
Metallothionein inhibited in a concentration-dependent fashion the reduction of nitroblue tetrazolium [NBT] mediated by xanthine oxidase and by NADH-phenazine methosulfate. This catalytic activity of metallothionein for dismutation of O2- is dependent on the copper content in metallothionein.