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Elucidation of the structure of the antineoplastic agents, 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones
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1977
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Medicinal ChemistryE ConfigurationHeterocyclicPharmaceutical ChemistryDerivative (Chemistry)Antineoplastic Agents1-Formylisoquinoline ThiosemicarbazonesNatural SciencesGeometrical IsomersChemical DerivativeOrganic ChemistryChemistryHeterocycle ChemistryPharmacologyZ IsomersSynthetic Chemistry
The geometrical isomers of the antineoplastic agents 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones were synthesized and their structure was studied by spectroscopic methods. It was found that the compounds previously described in the literature and tested for carcinostatic activity were isomers with E configuration which probably contained minor amounts of Z isomers.