Immunization with Alpha-Toxin Toxoid Protects the Cornea against Tissue Damage during Experimental <i>Staphylococcus aureus</i> Keratitis

Abstract

Alpha-toxin is a major virulence factor in Staphylococcus aureus keratitis. Active or passive immunization with alpha-toxin toxoid could protect against corneal damage. Results show that either form of immunization did not kill bacteria but did significantly protect against corneal pathology, especially epithelial erosion.