Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor γ

Abstract

Our data provides a novel insight into an effect of telmisartan: telmisartan inhibits AT1R gene expression through PPARgamma activation. The dual inhibition of angiotensin II function by telmisartan - AT1R blockade and downregulation - would contribute to more complete inhibition of the renin-angiotensin system.