Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice

The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane.

Robert R. H. Anholt, Peter L. Pedersen, E B De Souza et al. · Journal of Biological Chemistry · 1986 · 691 citations · Full text

Medicine, Biochemistry, Pharmacology +11

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

Kelvin W. Gee, Michael B. Bolger, Roberta Dı́az Brinton et al. · Journal of Pharmacology and Experimental Therapeutics · 1988 · 467 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

Daniel Bitran, Robert J. Hilvers, Carol K. Kellogg · Brain Research · 1991 · 457 citations · Full text

Medicine, Neuroscience, Pharmacology +12

Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP

Cheryl A. Frye, Sandra M. Petralia, Madeline E. Rhodes · Pharmacology Biochemistry and Behavior · 2000 · 442 citations

Medicine, Neurobiology, Neuroscience +17

Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABA_A Receptors

Daniel Bitran, Michael Shiekh, Michael K. McLeod · Journal of Neuroendocrinology · 1995 · 392 citations

Medicine, Neuroscience, Pharmacology +16