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Induction of LH Surges by Continuous Infusion of LH-RH
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1976
Year
Proestrous RatsSocial SciencesPituitary GlandNeuroendocrine MechanismPituitary DiseaseContinuous InfusionAnimal PhysiologyGrowth HormonePituitary Lh StoresPlasma InstabilityNeuropharmacologyNervous SystemEndocrinologyNeurophysiologyPhysiologyNeuroscienceElectrophysiologyMedicinePreovulatory Lh Surges
Preovulatory LH surges were measured in cannulated proestrous rats. Such LH peaks were also obtained by infusing pentobarbital-blocked animals with LH-RH for periods of up to 20 h; this suggested that the pituitary LH stores were exhausted. However, the total amount of LH secreted appeared more or less determined by the LH-RH dose, indicating that the size of the releasable LH pool is not fixed.