Concepedia

Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: A hypothesis

Kenneth Blum, Thomas J.H. Chen, Brian Meshkin, Roger L. Waite, Bernard W. Downs, Seth H. Blum, Julie F. Mengucci, Vanessa Arcuri, Eric R. Braverman, Tomás Palomo

Medical Hypotheses · 2007 · 50 citations · 60 references

DOI

Concepts

References

60

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

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Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders

Herbert M. Lachman, Demitri F. Papolos, Takuya Saito et al. · Pharmacogenetics · 1996 · 1.8K citations

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Functional Imaging of Neural Responses to Expectancy and Experience of Monetary Gains and Losses

Itzhak Aharon, Daniel Kahneman, Anders M. Dale et al. · Neuron · 2001 · 1.4K citations · Full text

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Association of Dopamine Transporter Reduction With Psychomotor Impairment in Methamphetamine Abusers

Nora D. Volkow, Linda Chang, Gene‐Jack Wang et al. · American Journal of Psychiatry · 2001 · 993 citations

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Low Level of Brain Dopamine D<sub>2</sub> Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex

Nora D. Volkow, Linda Chang, Gene-Jack Wang et al. · American Journal of Psychiatry · 2001 · 914 citations

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