Concepedia

Synthesis of Azetidin-2-Ones from Imines and Acids Using Trichloroacetonitrile-Triphenylphosphine Reagent

Vidyesh V. Govande, Malavika Arun, A.R.A.S. Deshmukh, B. M. Bhawal

Synthetic Communications · 2000 · 11 citations · 12 references

Concepts

Combinatorial ChemistryBioorganic ChemistryHeterocyclicNatural SciencesOrganic ChemistryStep SynthesisChemistryHeterocycle ChemistryPharmacologySynthetic Chemistry

Abstract

Abstract A one step synthesis of azetidin-2-ones (3a-j) has been described by the reaction of imines (1) with acids (2) in presence of trichloroacetonitrile, triphenylphosphine and triethylamine.

References

12

A mild and efficient procedure for the preparation of acid chlorides from car☐ylic acids

Doo Ok Jang, Doo Jin Park, Joong‐Gon Kim · Tetrahedron Letters · 1999 · 81 citations

Chemical Engineering, Engineering, Acid Chlorides +4

An improved method for the stereoselective synthesis of β-lactams from carboxylic acids and imines

Gunda I. Georg, Peter M. Mashava, Xiangming Guan · Tetrahedron Letters · 1991 · 55 citations

Carboxylic Acids, Improved Method, Engineering +9

Reagents and synthetic methods. Part 67. Preparation of 4-unsubstituted .beta.-lactams from 4-acetoxyazetidin-2-ones. A formal approach to monobactams and nocardicins

Ana Arrieta, Begoña Lecea, Fernando P. Cossío et al. · The Journal of Organic Chemistry · 1988 · 48 citations

Engineering, Biochemistry, Synthetic Methods +12

Cyanuric Chloride: A Mild Reagent for β-Lactam Synthesis

M. S. MANHAS, Ajay K. Bose, Mohammad S. Khajavi · Synthesis · 1981 · 40 citations

Pharmacology, Organic Chemistry, Synthetic Chemistry +1

Synthesis of β-lactams through the reaction of mixed anhydrides and imines

Ajay K. Bose, J. C. Kapur, Shweta Sharma et al. · Tetrahedron Letters · 1973 · 40 citations

Engineering, Biochemistry, Natural Sciences +6