Concepedia

Tolerance Induction in HLA Disparate Living Donor Kidney Transplantation by Donor Stem Cell Infusion

Joseph R. Leventhal, Michaël Abécassis, Joshua Miller, Lorenzo Gallon, David J. Tollerud, Mary Jane Elliott, Larry D. Bozulic, Christopher Houston, Nedjema Sustento‐Reodica, Suzanne T. Ildstad

Transplantation · 2012 · 151 citations · 18 references

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Abstract

Low-intensity conditioning plus FCRx safely achieved durable chimerism in mismatched allograft recipients. Sensitization represents an obstacle to successful induction of chimerism. Sustained T-cell chimerism is a more robust biomarker of tolerance than donor-specific hyporeactivity.

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Chimerism and Tolerance Without GVHD or Engraftment Syndrome in HLA-Mismatched Combined Kidney and Hematopoietic Stem Cell Transplantation

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