Tolerance Induction in HLA Disparate Living Donor Kidney Transplantation by Donor Stem Cell Infusion

Abstract

Low-intensity conditioning plus FCRx safely achieved durable chimerism in mismatched allograft recipients. Sensitization represents an obstacle to successful induction of chimerism. Sustained T-cell chimerism is a more robust biomarker of tolerance than donor-specific hyporeactivity.

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