Direct Solid‐Phase Glycosylations of Peptide Templates on a Novel PEG‐Based Resin

Abstract

Glycopeptide libraries in which both the carbohydrate part and the peptide part have been varied can be generated by stereoselctive glycosylation of free hydroxy groups of support-bound peptides with glycosyl trichloroacetimidates. The use of temporary t Bu protecting groups enabled the stereoselctive synthesis of a model library of four glycopeptides (one is depicted on the right) that each have two different glycosyl groups.