Publication | Closed Access
Effects of Prolonged Dopamine Infusion on Anterior Pituitary Function in Normal Males*
142
Citations
0
References
1981
Year
Human GrowthAnterior Pituitary FunctionReproductive EndocrinologyPituitary GlandNeuroendocrine MechanismPituitary DiseaseClinical ChemistryProlonged Dopamine InfusionSm LevelsHealth SciencesGrowth HormoneInherited Metabolic DiseaseClinical NutritionNeuropharmacologyChronic SomatomedinPediatric EndocrinologyDevelopmental EndocrinologyDopamineEndocrinologyPlacental FunctionDopamine ResearchClinical DisordersGh DeficiencyNeurophysiologyPhysiologyPediatricsNeuroscienceMedicine
The correlation between acute and chronic somatomedin (SM) response to hGH treatment of hypopituitary dwarfism and the value of SM levels in predicting growth rates were investigated in 20 children with GH deficiency. Plasma samples for SM determinations were obtained before treatment, 12–14 h after each of 4 daily injections of hGH (0.1 U/kg) and after 6 months of hGH (0.1 U/kg 3 times per week). Mean plasma SM-C levels by placental membrane radioreceptor assay rose from 0.39 ± 0.05 U/ml (mean ± SEM) on day 1 to 1.18 ± 0.14 U/ml on day 5 and measured 0.95 ± 0.12 U/ml at 6 months. By RIA, mean plasma SM-C levels rose from 0.19 ± 0.03 U/ml on day 1 to 0.82 ± 0.11 U/ml on day 5 and measured 0.79 ± 0.11 U/ml at 6 months. However, individual SM responses to acute and chronic hGH treatment were highly variable, with 7 children raising SM-C levels above 1 U/ml (RIA) by day 5, while 3 children maintained SM levels less than 0.1 U/ml. The latter 3 had persistently low SM levels at 6 months (<0.20 U/ml), despite g...