Multifunctional Skin‐Like Electronics for Quantitative, Clinical Monitoring of Cutaneous Wound Healing

TLDR

Non‑invasive biomedical devices can deliver quantitative data for skin disease and wound assessment, whereas conventional methods depend on qualitative judgments or instruments that cannot be intimately integrated with skin near wounds. This study presents an electronic sensor platform that softly and reversibly laminates around wounds to provide highly accurate quantitative data for managing surgical wound healing. Clinical trials employing thermal sensors and actuators arranged in fractal layouts enable precise, time‑dependent mapping of skin temperature and thermal conductivity adjacent to wounds. Analytical and simulation analyses establish the sensing fundamentals, system mechanics, and design optimizations, while clinical use demonstrates practical disinfection, reuse protocols, and quantitative measurement procedures that could meet unmet needs in chronic wound care.

Abstract

Non‐invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time‐dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of “epidermal” electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management.